Saka created Gabriel Martinelli’s fifth-minute opener on Sunday at Emirates Stadium, becoming the third-youngest player to 20 Premier League assists (aged 21 years and 55 days).
The England international appeared in some discomfort in the 15th minute, though, requiring medical treatment after what seemed to be a left-ankle injury following a challenge from Renan Lodi.
Saka attempted to continue but again went down after 26 minutes, with Mikel Arteta withdrawing the winger with Reiss Nelson replacing him.
England will be hopeful the injury to Saka proves not to be too serious, with their World Cup opener against Iran set for November 21.
With Reece James, Harry Maguire, John Stones, Kyle Walker and Kalvin Phillips all battling injuries, Gareth Southgate will hope Saka has just suffered a knock and not a serious setback.