The former Liverpool forward was taken off just 20 minutes into Bayern’s 6-1 win over Bremen on Tuesday night.
According to L’Equipe, he will play no part in the competition, dealing the reigning Africa Cup of Nations champions a massive blow.
His Bayern boss Julian Nagelsmann said the player would have an X-ray to determine the extent of the injury after initially saying he had taken a blow to his tibia – and that he was hopeful it was ‘not a big injury’.
‘He took a knock to the head of his tibia,’ he said. ‘It’s always uncomfortable. He has to have an X-ray. I hope nothing is wrong.
‘I didn’t see him after the game, I hope it’s not a big injury. But I don’t know at the moment’, the Bayern boss continued. ‘We’ll see tomorrow and then give an update.’
Mane, who joined Bayern from Liverpool for £35million in the summer, has been an exciting for his club during his first season in Germany. He’s scored 11 goals in 23 appearances in all competitions, laying on four assists.